DOI:
10.1055/s-00000083
Synlett
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Another advantage of the second-generation route is that the enantioselective Sharpless dihydroxylation adds another filter for the purity of the product, because the C4 epimer left over from the Mukaiyama–Michael step is removed in the recrystallization of alcohol 7. The improvement of purity in two consecutive enantioselective steps is a manifestation of the Horeau principle; see: Vigneron JP, Dhaenes M, Horeau A.
Tetrahedron 1973;
29: 1055
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