Synthesis of Benzoazepinone Derivatives via Photoredox Deaminative Radical Cascade Alkylation of 1,7-Dienes and 1,7-Enynes

Abstract

A deaminative alkyl radical cascade cyclization of 1,7-dienes is described under visible-light photocatalysis. This method delivers a family of benzoazepinones (benzazepinones) and occurs under mild reaction conditions to access a broad substrate scope with excellent functional group tolerance and good yields. This protocol has also been extended to 1,7-enynes, furnishing a representative collection of cyclopentaquinolinones.

Key words

benzazepinones - photocatalysis - cyclopentaquinolinones - cyclization - 1,7-enynes - N-heterocycles

Publication History

Received: 23 August 2022

Accepted after revision: 29 September 2022

Accepted Manuscript online:
29 September 2022

Article published online:
20 December 2022

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