Synlett 2024; 35(01): 21-28
DOI: 10.1055/a-2071-4549
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Functional Dyes

Near-Infrared Hemicyanine Fluorophores with Optically Tunable Groups: A ‘Leap Forward’ for in Vivo Sensing and Imaging

Jing Huang‡
a   State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, P. R. of China
,
Long He‡
a   State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, P. R. of China
,
Jiaoliang Wang∗
b   College of Materials and Chemical Engineering, Hunan City University, Yiyang 413000, Hunan, P. R. of China
,
Junchao Xu∗
a   State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, P. R. of China
,
Lin Yuan∗
a   State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, P. R. of China
› Author AffiliationsWe would like to thank the Natural Science Foundation of Hunan Province (2021JJ30073) (J.W.), and the National Natural Science Foundation of China (NSFC) (22074036) (L.Y.).
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Abstract

Hemicyanine dyes, with a tunable optical site and high wavelength tailorability, are of significant importance in the fields of sensing and diagnosis. Following the discovery of the near-infrared (NIR) (650–900 nm) fluorescent dyes Changsha (CS) and Huda (HD) by our group, remarkable progress has been made in the development of hemicyanine-based probes for in vivo imaging and detecting. In this review, we summarize the key contributions made by our group in developing long-wavelength (650–1700 nm) hemicyanines and utilizing them to construct functional probes. Finally, potential drawbacks and future prospects of hemicyanine dyes/probes are discussed.

1 Introduction

2 Changsha (CS) Dyes

3 Huda (HD) Dyes

4 Construction of Hemicyanine Fluorophores in the NIR-II Region

5 Summary and Outlook

Key words

near-infrared - fluorophore - hemicyanine - molecular probe - fluorescence imaging


Publication History

Received: 13 March 2023

Accepted after revision: 11 April 2023

Accepted Manuscript online:
11 April 2023

Article published online:
01 June 2023

© 2023. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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