Alkyne-Based Cascade Strategies for the Construction of Diverse Carbo/Heterocycles

Carbocycles/Heterocycles are fundamental structural motifs in natural products, pharmaceuticals, and functional materials. Alkyne based cascade strategies have emerged as powerful tools for the efficient construction of these frameworks, enabling rapid access to diverse ring systems through domino cyclization pathways. This account highlights the representative recent advances of alkynemediated cascade reactions, covering transition-metal catalysis and acid-mediated reactions. These methods facilitate multiple bond forming events in a single operation, offering high atom and step economy. Special focus is given to illustrative transformations, mechanistic insights, and the broad utility of alkynes as precursors for the concise synthesis of diverse carbocyclic and heterocyclic molecular frameworks.

Publication History

Received: 30 June 2025

Accepted after revision: 28 July 2025

Accepted Manuscript online:
29 July 2025