Download PDF
Synfacts 2009(3): 0234-0234  
DOI: 10.1055/s-0028-1087699
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Theopederin D

Contributor(s): Philip Kocienski, Stewart Eccles
M. E. Green, J. C. Rech, P. E. Floreancig*
University of Pittsburgh, USA
Further Information

Publication History

Publication Date:
19 February 2009 (online)

    Permissions and Reprints

Significance

Theopederin D was isolated from a marine sponge of the genus Theonella. It exhibits a range of biological properties including immunosuppressive and antiviral activity as well as a 2 nM IC50 value against murine P388 leukemia cells. Noteworthy in the synthesis is the trioxadecalin formation (F → G) by an electron-transfer-initiated cyclization (ETIC).