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Synfacts 2009(3): 0276-0276  
DOI: 10.1055/s-0028-1087768
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Unexpectedly Accessing a New Class of Cyanine-Derived Dyes

Contributor(s): Timothy M. Swager, Ryan M. Moslin
H. Lee, M. Y. Berezin, K. Guo, J. Kao, S. Achilefu*
Washington University, St. Louis, USA
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

The authors have developed a synthetically flexible way to convert commercially available cyanine dyes into near-infrared uracile derivatives in a single step. The compounds demonstrate a clear change in fluorescence with changing pH and are presented as potential fluorescent pH-sensitive probes.