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Synfacts 2009(4): 0357-0357
DOI: 10.1055/s-0028-1088091
DOI: 10.1055/s-0028-1088091
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (-)-Podophyllotoxin
D. Stadler, T. Bach*
Technische Universität München, Garching, Germany
Further Information
Publication History
Publication Date:
23 March 2009 (online)
Significance
Podophyllotoxin is obtained from the rhizome of American mayapple. It possesses some cytotoxic and antiviral properties. The short synthesis depicted features an iron(III)-catalyzed diastereoselective Friedel-Crafts alkylation (C → E).