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Synfacts 2009(7): 0763-0763  
DOI: 10.1055/s-0029-1217269
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Asymmetric Cyclopentanes through a Domino Reaction

Contributor(s): Mark Lautens, Jane Panteleev
R. Unger, F. Weisser, N. Chinkov, A. Stanger, T. Cohen, I. Marek*
Technion-Israel Institute of Technology, Haifa, Israel and University of Pittsburgh, USA
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

An enantioselective Zn-ene-allene cyclization is utilized in a tandem process accessing chiral cyclopentanes. Although the enantio­selectivities achieved are moderate, the diastereocontrol of the transformation is exceptional.