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Synfacts 2009(10): 1127-1127  
DOI: 10.1055/s-0029-1217845
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Conjugate Addition of Dimethylzinc to Meldrum’s Acids

Contributor(s): Mark Lautens, Chit Tsui
A. Wilsily, T. Lou, E. Fillion*
University of Waterloo, Canada
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

The authors describe an enantio­selective copper-catalyzed conjugate addition of dimethylzinc to alkylidene Meldrum’s acids in the presence of the chiral phosphoramidite 3. The products having all-carbon quaternary stereocenters (methyl-containing) can be obtained in good to excellent yields and enantioselectivities.