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Synfacts 2009(10): 1134-1134  
DOI: 10.1055/s-0029-1217846
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

An Iterative Approach to the Total Synthesis of (+)-Faranal

Contributor(s): Mark Lautens, David A. Candito
G. Dutheuil, M. P. Webster, P. A. Worthington, V. K. Aggarwal*
University of Bristol and Syngenta, Bracknell, UK
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

The authors previously reported a stereoselective method to homologate carbon chains bearing boronic esters (Angew. Chem. Int. Ed. 2007, 46, 7491). Here, they demonstrate the power of this methodology in the total synthesis of (+)-faranal and highlight an impressive one-pot homologation process.