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Synfacts 2009(10): 1111-1111
DOI: 10.1055/s-0029-1217851
DOI: 10.1055/s-0029-1217851
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Cu-Catalyzed Decarboxylative Asymmetric Mannich-Type Reaction
L. Yin, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
Further Information
Publication History
Publication Date:
22 September 2009 (online)
Significance
The synthesis of β²,²,³-amino acid precursors via a copper-catalyzed decarboxylative Mannich-type reaction is described. Hydrolysis of these precursors under acidic conditions then allows for the preparation of enantiomerically enriched amino acid derivatives.