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Synfacts 2009(10): 1119-1119
DOI: 10.1055/s-0029-1217854
DOI: 10.1055/s-0029-1217854
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Cr-Catalyzed Intramolecular Addition of Tertiary Enamides to Ketones
L. Yang, D.-X. Wang, Z.-T. Huang, M.-X. Wang*
Institute of Chemistry, Chinese Academy of Sciences and Tsinghua University, Beijing, P. R. of China
Further Information
Publication History
Publication Date:
22 September 2009 (online)
Significance
As an extension on previous work involving reactions of tertiary enamides with epoxides (Org. Lett. 2008, 10, 2461), the authors now describe the chromium-catalyzed intramolecular nucleophilic addition of tertiary enamides to ketones. The resulting 1H-pyrrol-2(3H)-one derivatives bearing a hydroxylated quaternary carbon center were obtained in good yield and with excellent enantioselectivity.