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Synfacts 2009(10): 1143-1143
DOI: 10.1055/s-0029-1217893
DOI: 10.1055/s-0029-1217893
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Ynamides via Iron-Catalyzed Amidation of Alkynyl Bromides
B. Yao, Z. Liang, T. Niu, Y. Zhang*
Zhejiang University, Hangzhou, P. R. of China
Further Information
Publication History
Publication Date:
22 September 2009 (online)
Significance
A straightforward access to ynamides via the direct coupling of alkynyl bromides with amides has been developed. This Csp-N coupling reaction is hereby catalyzed by FeCl3˙6H2O with N,N′-dimethylethane-1,2-dimethylamine (DMEDA) as ligand.