Synthesis of a CETP Inhibitor

T. A. Rano; G.-H. Kuo

doi:10.1055/s-0029-1218324

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Synfacts 2009(12): 1306-1306
DOI: 10.1055/s-0029-1218324

Synthesis of Natural Products and Potential Drugs

Synthesis of a CETP Inhibitor

Contributor(s): Philip Kocienski
T. A. Rano*, G.-H. Kuo
Johnson & Johnson Pharmaceutical Research and Development, Raritan, USA

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Publication History

Publication Date:
20 November 2009 (online)

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Significance

Inhibition of cholesteryl ester transfer protein (CETP) leads to elevation of plasma high density lipoprotein cholesterol (”good" cholesterol) and lowering of plasma low density lipoprotein cholesterol (”bad" cholesterol) with an ensuing beneficial plasma lipid profile.