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Synfacts 2011(10): 1119-1119
DOI: 10.1055/s-0030-1261079
DOI: 10.1055/s-0030-1261079
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Pd-Catalyzed Synthesis of (Het)Ar-SCF3 Compounds
G. Teverovskiy, D. S. Surry, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
Further Information
Publication History
Publication Date:
20 September 2011 (online)
Significance
Herein, the first general method for a Pd-catalyzed Ar-SCF3 bond formation is disclosed. Both aryl and (hetero)aryl bromides readily undergo cross-coupling reactions with trifluoromethyl thiolate to give the corresponding (hetero)aryl sulfides in good to excellent yields.