Am J Perinatol 2016; 33(14): 1382-1387
DOI: 10.1055/s-0036-1582445
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Pregnancy and Brain Death: Lack of Guidance in U.S. Hospital Policies

Ariane Lewis
1   Division of Neurocritical Care, Departments of Neurology and Neurosurgery, NYU Langone Medical Center, New York, New York
,
Panayiotis Varelas
2   Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, Michigan
,
David Greer
3   Department of Neurology, Yale University School of Medicine, New Haven, Connecticut
› Author Affiliations
Further Information

Publication History

22 February 2016

29 February 2016

Publication Date:
09 May 2016 (online)

Abstract

Objective The death of Marlise Muñoz, a pregnant woman who suffered an anoxic brain injury in November 2013, highlights the social, ethical, legal, and medical controversies associated with brain death in pregnancy. We sought to evaluate whether institutions in the United States have policies in place for situations in which a pregnant woman is declared brain dead.

Study Design Institutional brain-death protocols from hospitals in the United States were obtained in cooperation with local and regional organ procurement agencies. Each protocol was reviewed to determine if and how it addressed brain death in pregnancy.

Results We reviewed 317 unique brain-death protocols. In eight protocols (2.5%), it was noted that a pregnant patient could not be evaluated for brain death if the fetus could be preserved. Of the protocols that permitted brain-death evaluation, 289 (93.8%) did not include guidance about fetal management after maternal brain death and 305 (99%) did not indicate who was responsible for making decisions for the fetus.

Conclusion Very few institutional brain-death policies address the issue of pregnancy. The creation of guidelines on management of the social and ethical challenges associated with brain death in pregnancy may be helpful.

Note

Ariane Lewis has no financial disclosure or conflict of interest. Panayiotis Varelas is a member of the advisory board of Gift of Life in Michigan. David Greer is the editor-in-chief of journal Seminars in Neurology. This article represents valid work and neither this article nor one with substantially similar content has been published or is being considered for publication elsewhere.


 
  • References

  • 1 Bernat JL. Whither brain death?. Am J Bioeth 2014; 14 (8) 3-8
  • 2 Gostin LO. Legal and ethical responsibilities following brain death: the McMath and Muñoz cases. JAMA 2014; 311 (9) 903-904
  • 3 Humphrey WA. “But I'm Brain-Dead and Pregnant”: advance directive pregnancy exclusions and end-of-life wishes. Wm & Mary J Women & L 2015; 21 (3) 669
  • 4 Burkle CM, Tessmer-Tuck J, Wijdicks EF. Medical, legal, and ethical challenges associated with pregnancy and catastrophic brain injury. Int J Gynaecol Obstet 2015; 129 (3) 276-280
  • 5 Mayo TW. Brain-dead and pregnant in Texas. Am J Bioeth 2014; 14 (8) 15-18
  • 6 Association of Organ Procurement Organizations (Internet). Available at: www.aopo.org
  • 7 Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research Electronic Data Capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42 (2) 377-381
  • 8 Liao S, Ito S. Brain death: ethical challenges to palliative care concepts of family care. J Pain Symptom Manage 2010; 40 (2) 309-313
  • 9 Burt RA. The medical futility debate: patient choice, physician obligation, and end-of-life care. J Palliat Med 2002; 5 (2) 249-254
  • 10 Esmaeilzadeh M, Dictus C, Kayvanpour E , et al. One life ends, another begins: Management of a brain-dead pregnant mother-A systematic review-. BMC Med 2010; 8: 74
  • 11 Fadel HE. Postmortem and perimortem cesarean section: historical, religious and ethical considerations. J IMA 2011; 43 (3) 194-200
  • 12 Spike J, Greenlaw J. Ethics consultation: persistent brain death and religion: must a person believe in death to die?. J Law Med Ethics 1995; 23 (3) 291-294
  • 13 Smith ML, Flamm AL. Accommodating religious beliefs in the ICU: a narrative account of a disputed death. Narrat Inq Bioeth 2011; 1 (1) 55-64
  • 14 Flamm AL, Smith ML, Mayer PA. Family members' requests to extend physiologic support after declaration of brain death: a case series analysis and proposed guidelines for clinical management. J Clin Ethics 2014; 25 (3) 222-237
  • 15 Dickens B ; FIGO Committee for Ethical Aspects of Human Reproduction and Women's Health. Brain death and pregnancy. Int J Gynaecol Obstet 2011; 115 (1) 84-85
  • 16 Farragher RA, Laffey JG. Maternal brain death and somatic support. Neurocrit Care 2005; 3 (2) 99-106
  • 17 Burkle CM, Schipper AM, Wijdicks EFM. Brain death and the courts. Neurology 2011; 76 (9) 837-841
  • 18 Krause M, Laubenberg J HB 1901. Texas Legislature. Legislative session: 84 (R). Council document: 84R 10465 JSC-F; 2015
  • 19 Powner DJ, Bernstein IM. Extended somatic support for pregnant women after brain death. Crit Care Med 2003; 31 (4) 1241-1249
  • 20 Suddaby EC, Schaeffer MJ, Brigham LE, Shaver TR. Analysis of organ donors in the peripartum period. J Transpl Coord 1998; 8 (1) 35-39
  • 21 Wawrzyniak J. Continuation of pregnancy in a woman with critical brain injury. Anaesthesiol Intensive Ther 2015; 47 (1) 40-44
  • 22 Dillon WP, Lee RV, Tronolone MJ, Buckwald S, Foote RJ. Life support and maternal death during pregnancy. JAMA 1982; 248 (9) 1089-1091
  • 23 Ramsay G, Paglia M, Bourjeily G. When the heart stops: a review of cardiac arrest in pregnancy. J Intensive Care Med 2013; 28 (4) 204-214
  • 24 European Resuscitation Council. Part 8: advanced challenges in resuscitation. Section 3: special challenges in ECC. 3F: cardiac arrest associated with pregnancy. Resuscitation 2000; 46 (1–3) 293-295
  • 25 Sheehy E, Conrad SL, Brigham LE , et al. Estimating the number of potential organ donors in the United States. N Engl J Med 2003; 349 (7) 667-674
  • 26 Burck R, Anderson-Shaw L, Sheldon M, Egan EA. The clinical response to brain death: a policy proposal. JONAS Healthc Law Ethics Regul 2006; 8 (2) 53-59
  • 27 Wijdicks EFM. Determining brain death in adults. Neurology 1995; 45 (5) 1003-1011
  • 28 Greer DM, Styer AK, Toth TL, Kindregan CP, Romero JM. Case records of the Massachusetts General Hospital. Case 21-2010. A request for retrieval of oocytes from a 36-year-old woman with anoxic brain injury. N Engl J Med 2010; 363 (3) 276-283
  • 29 Nakhuda GS. Posthumous assisted reproduction. Semin Reprod Med 2010; 28 (4) 329-335
  • 30 Hans JD. Posthumous gamete retrieval and reproduction: would the deceased spouse consent?. Soc Sci Med 2014; 119: 10-17
  • 31 Spielman B. Pushing the dead into the next reproductive frontier: post mortem gamete retrieval under the uniform anatomical gift act. J Law Med Ethics 2009; 37 (2) 331-343