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Synthesis 2017; 49(16): 3726-3730
DOI: 10.1055/s-0036-1588421
DOI: 10.1055/s-0036-1588421
paper
An Efficient and Modular Route to C3*-TunePhos-Type Ligands
We are grateful for the financial support by a grant from Wuhan University (203273463), ‘111’ Project of the Ministry of Education of China and the National Natural Science Foundation of China (Grant No. 21302193, 21372179, 21432007, 21402145).Further Information
Publication History
Received: 25 February 2017
Accepted after revision: 17 April 2017
Publication Date:
11 May 2017 (online)
Abstract
An efficient and modular synthetic route to the bidentate C3*-TunePhos was developed, which allowed tunable steric and electronic effects of the ligands. This novel chemical technology highlights a versatile C3*-dibromodiphenyl intermediate that was accomplished by in situ Grignard exchange and subsequent Cu(II)-mediated intramolecular oxidative radical coupling process. It is worth noting that this advanced intermediate not only could be easily prepared by a diverse array of C3*-TunePhos-type ligands, but also could be used to facile synthesis of other novel type of N,S-centered bidentate ligands.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588421.
- Supporting Information
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