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Synlett 2020; 31(05): 421-433
DOI: 10.1055/s-0039-1691580
DOI: 10.1055/s-0039-1691580
account
Total Synthesis of Natural Products Using Intramolecular Nozaki–Hiyama–Takai–Kishi Reactions
This work was supported by the MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2012–2016, Japan Society for the Promotion of Science (JSPS), Grants-in-Aid for Scientific Research (KAKENHI) (Grant Nos. 15750094 and 15K05504) from Japan Society for the Promotion of Science (JSPS), the Naito Foundation, and the Keio Gijuku Academic Development Funds.Further Information
Publication History
Received: 08 December 2019
Accepted after revision: 29 December 2019
Publication Date:
03 February 2020 (online)
Abstract
In this Account, we describe our studies on the total synthesis of several natural products using intramolecular Nozaki–Hiyama–Takai–Kishi (NHTK) reactions. In each synthesis, an NHTK reaction is used to efficiently construct a medium-sized ring. These examples demonstrate the utility of the intramolecular NHTK reaction in natural product synthesis.
1 Introduction
2 Total Synthesis of (+)-Pestalotiopsin A
3 Total Synthesis of (+)-Cytosporolide A
4 Total Synthesis of (+)-Vibsanin A
5 Total Syntheses of (+)-Aquatolide and Related Humulanolides
6 Conclusion
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References
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For synthetic studies of pestalotiopsin A, see: