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Am J Perinatol 2021; 38(06): 602-608
DOI: 10.1055/s-0039-1700858
Original Article

Executive Functions and Academic Outcomes of Low Birthweight Infants: A Prospective Longitudinal U.S. Cohort

Sarah E. Miller
1   Division of Neonatology, Department of Pediatrics, University of Virginia Children's Hospital, Charlottesville, Virginia
,
Mark D. DeBoer
2   Division of Pediatric Diabetes and Endocrinology, Department of Pediatrics, University of Virginia Children's Hospital, Charlottesville, Virginia
,
Rebecca J. Scharf
3   Division of Neurodevelopmental and Behavioral Pediatrics, Department of Pediatrics, University of Virginia Children's Hospital, Charlottesville, Virginia
› Author Affiliations Funding This work was supported by the Doris Duke Charitable Foundation Clinical Scientist Development Award (R. J. S.).
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Abstract

Objective Executive functions such as working memory and cognitive flexibility are key to lifelong learning. Our hypothesis was that children born low birthweight (LBW), defined as weight < 2,500 g, would have lower cognitive outcomes than those born normal weight, and children with poor executive functioning would be at risk for poor academic outcomes.

Study Design We evaluated data from 12,656 children followed prospectively in the Early Childhood Longitudinal Study, Kindergarten Class 2010–2011, assessing outcomes from kindergarten, first grade, and second grade. Multivariable linear and logistic regressions were run evaluating the relationship between birthweight and cognitive outcomes, and the odds of infants with poor executive functioning having poor academic outcomes.

Results Compared with children with normal birthweight, those born LBW had lower mean z-scores for academic and directly assessed executive functions from kindergarten through second grade. LBW children were at an increased risk of scoring in the bottom 20% of children at all time points: second-grade reading odds ratio (OR) = 1.60 (95% confidence interval [CI:] 1.23–2.09), math OR = 1.49 (95% CI: 1.21–1.84), science OR = 1.41 (95% CI: 1.11–1.81), cognitive flexibility OR = 1.61 (95% CI: 1.27–2.02), and working memory OR = 1.40 (95% CI: 1.10–1.77).

Conclusion LBW infants remain at risk of poor cognitive outcomes in second grade. Early difficulties with executive functioning can increase the risk of a child's academic performance years later.

Keywords

low birthweight - executive function - developmental outcomes - school-aged children

Supplementary Material



Publication History

Received: 21 June 2019

Accepted: 23 September 2019

Article published online:
30 December 2019

© 2019. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
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