J Hand Microsurg
DOI: 10.1055/s-0043-1760767
Review Article

Vascularized Reconstruction of Recalcitrant Clavicular Nonunion with the Medial Femoral Condyle Free Flap: A Systematic Review of the Literature

1   Department of Plastic and Reconstructive Surgery, Bankstown-Lidcombe Hospital, Sydney, NSW, Australia
,
Pascalino Bruno Romeo
2   Department of Plastic and Reconstructive Surgery, Nepean Hospital, Sydney, NSW, Australia
› Author Affiliations

Abstract

Recalcitrant clavicular nonunion is an uncommon but challenging problem. Vascularized bone reconstruction is not first-line therapy due to complexity and donor morbidity, though it has utility in select cases. A systematic review of Embase and Medline databases was undertaken for cases of medial femoral condyle reconstruction for clavicle nonunion. Ten studies met inclusion, encompassing 26 patients. Mean age was 38.9 years. Ten patients were male and 16 female. Mean time of nonunion was 37.79 months prior to intervention; mean time to union following medial femoral condyle flap was 7.60 months. Two patients did not achieve union. Of the 11 patients who previously had at least one failed fixation with bone graft, considered the current “gold standard”, 9 patients (81.81%) went on to achieve union, while 2 patients (18.19%) did not. There were six reported complications in five patients. Medial femoral condyle flap is a valuable option in recalcitrant clavicle nonunion.



Publication History

Article published online:
13 March 2023

© 2023. Society of Indian Hand Surgery & Microsurgeons. All rights reserved.

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  • References

  • 1 Choudry UH, Bakri K, Moran SL, Karacor Z, Shin AY. The vascularized medial femoral condyle periosteal bone flap for the treatment of recalcitrant bony nonunions. Ann Plast Surg 2008; 60 (02) 174-180
  • 2 Doi K, Sakai K. Vascularized periosteal bone graft from the supracondylar region of the femur. Microsurgery 1994; 15 (05) 305-315
  • 3 Lenza M, Belloti JC, Gomes Dos Santos JB, Matsumoto MH, Faloppa F. Surgical interventions for treating acute fractures or non-union of the middle third of the clavicle. Cochrane Database Syst Rev 2009; (04) CD007428
  • 4 Neer II CS. Nonunion of the clavicle. J Am Med Assoc 1960; 172: 1006-1011
  • 5 Rowe CR. An atlas of anatomy and treatment of midclavicular fractures. Clin Orthop Relat Res 1968; 58 (58) 29-42
  • 6 Hill JM, McGuire MH, Crosby LA. Closed treatment of displaced middle-third fractures of the clavicle gives poor results. J Bone Joint Surg Br 1997; 79 (04) 537-539
  • 7 McKee MD, Pedersen EM, Jones C. et al. Deficits following nonoperative treatment of displaced midshaft clavicular fractures. J Bone Joint Surg Am 2006; 88 (01) 35-40
  • 8 Nowak J, Holgersson M, Larsson S. Sequelae from clavicular fractures are common: a prospective study of 222 patients. Acta Orthop 2005; 76 (04) 496-502
  • 9 Robinson CM, Court-Brown CM, McQueen MM, Wakefield AE. Estimating the risk of nonunion following nonoperative treatment of a clavicular fracture. J Bone Joint Surg Am 2004; 86 (07) 1359-1365
  • 10 Zlowodzki M, Zelle BA, Cole PA, Jeray K, McKee MD. Evidence-Based Orthopaedic Trauma Working G, Evidence-Based Orthopaedic Trauma Working Group. Treatment of acute midshaft clavicle fractures: systematic review of 2144 fractures: on behalf of the Evidence-Based Orthopaedic Trauma Working Group. J Orthop Trauma 2005; 19 (07) 504-507
  • 11 Endrizzi DP, White RR, Babikian GM, Old AB. Nonunion of the clavicle treated with plate fixation: a review of forty-seven consecutive cases. J Shoulder Elbow Surg 2008; 17 (06) 951-953
  • 12 Ramoutar DN, Rodrigues J, Quah C, Boulton C, Moran CG. Judet decortication and compression plate fixation of long bone non-union: Is bone graft necessary?. Injury 2011; 42 (12) 1430-1434
  • 13 Lenza M, Buchbinder R, Johnston RV, Ferrari BA, Faloppa F. Surgical versus conservative interventions for treating fractures of the middle third of the clavicle. Cochrane Database Syst Rev 2019; 1: CD009363
  • 14 Devaraj VS, Kay SP, Batchelor AG. Vascularised reconstruction of the clavicle. Br J Plast Surg 1990; 43 (05) 625-627
  • 15 Meals RA, Lesavoy MA. Vascularized free radius transfer for clavicle reconstruction concurrent with below elbow amputation. J Hand Surg Am 1987; 12 (5 Pt 1): 673-676
  • 16 Lim KA, Lin CH, Lin CH. A 19-year experience with clavicular defects: an algorithm for flap selection and surgical outcomes. Ann Plast Surg 2021; 86 (05) 562-567
  • 17 Zhou KJ, Graham DJ, Stewart D, Lawson RD, Sivakumar BS. Free medial femoral condyle flap for reconstruction of scaphoid nonunion: a systematic review. J Reconstr Microsurg 2022; 38 (08) 593-603
  • 18 Fuchs B, Steinmann SP, Bishop AT. Free vascularized corticoperiosteal bone graft for the treatment of persistent nonunion of the clavicle. J Shoulder Elbow Surg 2005; 14 (03) 264-268
  • 19 Hamada Y, Hibino N, Kobayashi A. Expanding the utility of modified vascularized femoral periosteal bone-flaps: an analysis of its form and a comparison with a conventional-bone-graft. J Clin Orthop Trauma 2014; 5 (01) 6-17
  • 20 Henn D, Abouarab MH, Hirche C. et al. Sequential chimeric medial femoral condyle and anterolateral thigh flow-through flaps for one-stage reconstructions of composite bone and soft tissue defects: report of three cases. Microsurgery 2017; 37 (07) 824-830
  • 21 Belyea CM, Lansford JL, Golden JB, Shin EH, Gumboc RDL. Medial femoral condyle vascularized bone graft for treatment of midshaft clavicle recalcitrant nonunion with use of the transverse cervical artery as an anastomosis. J Am Acad Orthop Surg Glob Res Rev 2020; 4 (06) e19.00049
  • 22 Jaloux C, Bettex Q, Levadoux M. et al. Free vascularized medial femoral condyle corticoperiosteal flap with non-vascularized iliac crest graft for the treatment of recalcitrant clavicle non-union. J Plast Reconstr Aesthet Surg 2020; 73 (07) 1232-1238
  • 23 Deng AD, Innocenti M, Arora R, Gabl M, Tang JB. Vascularized small-bone transfers for fracture nonunion and bony defects. Clin Plast Surg 2020; 47 (04) 501-520
  • 24 Chieh-Ting Huang T, Sabbagh MD, Lu CK, Steinmann SP, Moran SL. The vascularized medial femoral condyle free flap for reconstruction of segmental recalcitrant nonunion of the clavicle. J Shoulder Elbow Surg 2019; 28 (12) 2364-2370
  • 25 Murai A, Tada K, Nakada M, Matsuta M, Hayashi K, Tsuchiya H. Use of a free vascularized medial femoral condyle flap for revision surgery in a pediatric patient with congenital pseudarthrosis of the clavicle. Case Rep Orthop 2020; 2020: 8872934
  • 26 Healy WL, White GM, Mick CA, Brooker Jr AF, Weiland AJ. Nonunion of the humeral shaft. Clin Orthop Relat Res 1987; (219) 206-213
  • 27 Haidukewych GJ, Sperling JW. Results of treatment of infected humeral nonunions: the Mayo Clinic experience. Clin Orthop Relat Res 2003; (414) 25-30
  • 28 Beredjiklian PK, Hotchkiss RN, Athanasian EA, Ramsey ML, Katz MA. Recalcitrant nonunion of the distal humerus: treatment with free vascularized bone grafting. Clin Orthop Relat Res 2005; (435) 134-139
  • 29 Wood MB. Free vascularized bone transfers for nonunions, segmental gaps, and following tumor resection. Orthopedics 1986; 9 (06) 810-816
  • 30 Hernández-Cortés P, Elizondo-Espósito D, Peña-Rodríguez C, Pajares-López M. Acromial vascularized graft pedicled on the acromial branch of the thoracoacromial trunk for treatment of clavicular pseudoarthrosis. J Shoulder Elbow Surg 2012; 21 (10) e9-e13
  • 31 Fillingham Y, Jacobs J. Bone grafts and their substitutes. Bone Joint J 2016; 98-B (1, Suppl A): 6-9
  • 32 Goldberg VM, Shaffer JW, Field G, Davy DT. Biology of vascularized bone grafts. Orthop Clin North Am 1987; 18 (02) 197-205
  • 33 Arata MA, Wood MB, Cooney III WP. Revascularized segmental diaphyseal bone transfers in the canine. An analysis of viability. J Reconstr Microsurg 1984; 1 (01) 11-19
  • 34 Muramatsu K, Ihara K, Doi K, Shigetomi M, Hashimoto T, Taguchi T. Reconstruction of massive femur defect with free vascularized fibula graft following tumor resection. Anticancer Res 2006; 26 (5B): 3679-3683
  • 35 Heller L, Phillips K, Levin LS. Pedicled osteocutaneous fibula flap for reconstruction in the lower extremity. Plast Reconstr Surg 2002; 109 (06) 2037-2042
  • 36 Masquelet AC, Romana MC, Penteado CV, Carlioz H. [Vascularized periosteal grafts. Anatomic description, experimental study, preliminary report of clinical experience]. Rev Chir Orthop Repar Appar Mot 1988; 74 (Suppl. 02) 240-243
  • 37 Sakai K, Doi K, Kawai S. Free vascularized thin corticoperiosteal graft. Plast Reconstr Surg 1991; 87 (02) 290-298
  • 38 Pulos N, Kollitz KM, Bishop AT, Shin AY. Free vascularized medial femoral condyle bone graft after failed scaphoid nonunion surgery. J Bone Joint Surg Am 2018; 100 (16) 1379-1386
  • 39 Pinder RM, Brkljac M, Rix L, Muir L, Brewster M. Treatment of scaphoid nonunion: a systematic review of the existing evidence. J Hand Surg Am 2015; 40 (09) 1797-1805.e3
  • 40 Giladi AM, Rinkinen JR, Higgins JP, Iorio ML. Donor-site morbidity of vascularized bone flaps from the distal femur: a systematic review. Plast Reconstr Surg 2018; 142 (03) 363e-372e
  • 41 Mehio G, Morsy M, Cayci C. et al. Donor-site morbidity and functional status following medial femoral condyle flap harvest. Plast Reconstr Surg 2018; 142 (05) 734e-741e
  • 42 Haines M, Baba M, Stewart DA. Iatrogenic femur fracture following medial femoral condyle flap harvest. J Hand Surg Am 2020; 45 (09) 885.e1-885.e3
  • 43 Camargo PR, Phadke V, Braman JP, Ludewig PM. Three-dimensional shoulder kinematics after total claviculectomy: a biomechanical investigation of a single case. Man Ther 2013; 18 (06) 620-623
  • 44 Chen Y, Yu X, Huang W, Wang B. Is clavicular reconstruction imperative for total and subtotal claviculectomy? A systematic review. J Shoulder Elbow Surg 2018; 27 (05) e141-e148
  • 45 Lenoir H, Williams T, Kerfant N, Robert M, Le Nen D. Free vascularized fibular graft as a salvage procedure for large clavicular defect: a two cases report. Orthop Traumatol Surg Res 2013; 99 (07) 859-863
  • 46 Adolfsson L, Lysholm J, Nettelblad H. Adverse effects of extensive clavicular resections and a suggested method of reconstruction. J Shoulder Elbow Surg 1999; 8 (04) 361-364
  • 47 Krishnan KG, Mucha D, Gupta R, Schackert G. Brachial plexus compression caused by recurrent clavicular nonunion and space-occupying pseudoarthrosis: definitive reconstruction using free vascularized bone flap-a series of eight cases. Neurosurgery 2008;62(5, Suppl 2):ONS461–ONS469, discussion 469–470
  • 48 Ottomeyer C, Taylor BC, Isaacson M, Martinez L, Ebaugh P, French BG. Midshaft clavicle fractures with associated ipsilateral acromioclavicular joint dislocations: incidence and risk factors. Injury 2017; 48 (02) 469-473
  • 49 Godina M. Early microsurgical reconstruction of complex trauma of the extremities. Plast Reconstr Surg 1986; 78 (03) 285-292
  • 50 Gopal S, Majumder S, Batchelor AG, Knight SL, De Boer P, Smith RM. Fix and flap: the radical orthopaedic and plastic treatment of severe open fractures of the tibia. J Bone Joint Surg Br 2000; 82 (07) 959-966
  • 51 Sommar P, Granberg Y, Halle M, Skogh AC, Lundgren KT, Jansson KA. Effects of a formalized collaboration between plastic and orthopedic surgeons in severe extremity trauma patients; a retrospective study. J Trauma Manag Outcomes 2015; 9: 3
  • 52 Pasquesoone L, Barry L, Sturbois-Nachef N, Duquennoy-Martinot V, Chantelot C, Guerre E. The interest of “ortho-plastic” collaboration in management of complex limb injury. Ann Chir Plast Esthet 2020; 65 (5-6): 423-446
  • 53 Yu P. The transverse cervical vessels as recipient vessels for previously treated head and neck cancer patients. Plast Reconstr Surg 2005; 115 (05) 1253-1258
  • 54 Schettini AV, Modarressi A, Ruegg E, Kalbermatten D, Pittet-Cuenod B. Transverse cervical vessels as a recipient site for microvascular reconstruction in vessel-depleted necks: a safe option. JPRAS Open 2021; 30: 6-12
  • 55 Kompatscher P, Manestar M, Schuster A, Lang A, Beer GM. The thoracoacromial vessels as recipient vessels in microsurgery and supermicrosurgery: an anatomical and sonographic study. Plast Reconstr Surg 2005; 115 (01) 77-83