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J Pediatr Infect Dis 2023; 18(05): 266-271
DOI: 10.1055/s-0043-1769120
Case Report

Plastic Bronchitis and Human Bocavirus: A Report of Three Cases

Asli Imran Yilmaz 
1   Department of Pediatric Pulmonology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
,
Ahmet Çopur
2   Department of Pediatrics, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
,
Havva Parlatan
2   Department of Pediatrics, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
,
Hanife Tuğçe Çağlar 
1   Department of Pediatric Pulmonology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
,
Gökçen Ünal
1   Department of Pediatric Pulmonology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
,
Fatih Ercan 
1   Department of Pediatric Pulmonology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
,
Abdullah Yazar 
2   Department of Pediatrics, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
,
Mehmet Özdemir
3   Department of Medical Microbiology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
,
Sevgi Pekcan 
1   Department of Pediatric Pulmonology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya, Türkiye
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Abstract

This study aims to investigate and analyze the clinical features of coexisting human bocavirus (HBoV) positivity and plastic bronchitis (PB). We present three cases with no known history of cardiac surgery who presented with cough, progressive dyspnea, and atelectasis. They tested positive for HBoV in a real-time polymerase chain reaction of both nasal lavage fluids. They were diagnosed with PB as a result of bronchoscopy and pathology. PB is a rare disease characterized by forming thick rigid casts in the tracheobronchial tree, which can progress to respiratory failure. While asthma or atopy-related type 1 PB was observed in one patient, two patients were diagnosed with PB, which was thought to have developed secondary to viral infections of unknown etiology. As far as we know, HBoV-associated PB cases are rare in the literature. Besides the commonly known infectious agents, we identified a relationship with HBoV in all the presented cases.

Keywords

atelectasis - bronchiolitis - bronchoscopy - human bocavirus - plastic bronchitis

Consent to Participate and Consent to Publish

Patients gave written permission to participate and be published and share the images.


Ethical Approval

The patients gave written consent to participate and be published and share the images.


Availability of Data and Materials

Data and materials cannot be used without permission.




Publication History

Received: 31 December 2022

Accepted: 24 April 2023

Article published online:
26 May 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
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  • References

  • 1 Deng J, Zheng Y, Li C, Ma Z, Wang H, Rubin BK. Plastic bronchitis in three children associated with 2009 influenza A(H1N1) virus infection. Chest 2010; 138 (06) 1486-1488
    CrossrefPubMedGoogle Scholar
  • 2 Rüegger CM, Bär W, Iseli P. Simultaneous atelectasis in human bocavirus infected monozygotic twins: was it plastic bronchitis?. BMC Pediatr 2013; 13: 209
    CrossrefPubMedGoogle Scholar
  • 3 Grutter G, Di Carlo D, Gandolfo F. et al. Plastic bronchitis after extracardiac Fontan operation. Ann Thorac Surg 2012; 94 (03) 860-864
    CrossrefPubMedGoogle Scholar
  • 4 Kim S, Cho HJ, Han DK. et al. Recurrent plastic bronchitis in a child with 2009 influenza A (H1N1) and influenza B virus infection. J Korean Med Sci 2012; 27 (09) 1114-1119
    CrossrefPubMedGoogle Scholar
  • 5 Lu Z, Zheng Y. Plastic bronchitis associated with adenovirus infection. Lancet Infect Dis 2018; 18 (04) 474
    CrossrefPubMedGoogle Scholar
  • 6 Ma X, Endo R, Ishiguro N. et al. Detection of human bocavirus in Japanese children with lower respiratory tract infections. J Clin Microbiol 2006; 44 (03) 1132-1134
    CrossrefPubMedGoogle Scholar
  • 7 Bowen A, Oudjhane K, Odagiri K, Liston SL, Cumming WA, Oh KS. Plastic bronchitis: large, branching, mucoid bronchial casts in children. AJR Am J Roentgenol 1985; 144 (02) 371-375
    CrossrefPubMedGoogle Scholar
  • 8 Brogan TV, Finn LS, Pyskaty Jr DJ. et al. Plastic bronchitis in children: a case series and review of the medical literature. Pediatr Pulmonol 2002; 34 (06) 482-487
    CrossrefPubMedGoogle Scholar
  • 9 Wang X, Song Z, Hu W, Song L. Clinical analysis of airway mucus embolism in children with mycoplasma pneumonia. Int J Pediatr 2017; 44: 656-658
    PubMedGoogle Scholar
  • 10 Chung JY, Han TH, Kim JS, Kim SW, Park CG, Hwang ES. Th1 and Th2 cytokine levels in nasopharyngeal aspirates from children with human bocavirus bronchiolitis. J Clin Virol 2008; 43 (02) 223-225
    CrossrefPubMedGoogle Scholar
  • 11 Bagasi AA, Howson-Wells HC, Clark G. et al. Human bocavirus infection and respiratory tract disease identified in a UK patient cohort. J Clin Virol 2020; 129: 104453
    CrossrefPubMedGoogle Scholar
  • 12 Shah SS, Drinkwater DC, Christian KG. Plastic bronchitis: is thoracic duct ligation a real surgical option?. Ann Thorac Surg 2006; 81 (06) 2281-2283
    CrossrefPubMedGoogle Scholar
  • 13 Wang L, Wang W, Sun JM. et al. Efficacy of fiberoptic bronchoscopy and bronchoalveolar lavage in childhood-onset, complicated plastic bronchitis. Pediatr Pulmonol 2020; 55 (11) 3088-3095
    CrossrefPubMedGoogle Scholar