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Synfacts 2005(3): 0292-0292
DOI: 10.1055/s-2005-921586
DOI: 10.1055/s-2005-921586
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Fluoropyrroles
K. Sakoda, J. Mihara, J. Ichikawa*
University of Tokyo, Japan
Further Information
Publication History
Publication Date:
22 November 2005 (online)
Significance
The synthesis of substituted 5-fluoro-3H-pyrroles by Pd-catalyzed cyclization of 1,1-difluoroalkene oxime derivatives in low to reasonable yields is reported. The corresponding monofluoroalkene, dichloroalkene, dibromoalkene and halogene-free alkene failed in this cross-coupling reaction, which shows that the presence of the two fluorines play an important role in the cyclization.