Download PDF
Synfacts 2006(1): 0002-0002  
DOI: 10.1055/s-2005-921666
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Spongistatin 1

Contributor(s): Philip Kocienski
I. Paterson*, D. Y.-K. Chen, M. J. Coster, J. L. Aceña, J. Bach, D. J. Wallace
Cambridge University, UK
Further Information

Publication History

Publication Date:
16 December 2005 (online)

    Permissions and Reprints

Significance

Spongistatin 1 (also known as Altohyrtin A) is one of the most potent antimitotic agents ever tested by the National Cancer Institute with a GI50 = 1.3 × 10-10 M in the NCI 60 human carcinoma cell line. The Cambridge synthesis is perhaps the acme of reagent- and substrate-controlled directed aldol reactions in polyketide synthesis.