Download PDF
Synfacts 2007(8): 0785-0785  
DOI: 10.1055/s-2007-968707
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Alstonerine

Contributor(s): Philip Kocienski, Thomas Snaddon
K. A. Miller, S. F. Martin*
the University of Texas at Austin, USA
Further Information

Publication History

Publication Date:
24 July 2007 (online)

    Permissions and Reprints

Significance

(-)-Alstonerine is an indole alkaloid that displays inhibitory activity against human lung cancer cell lines. Key to this synthesis is (1) the use of a Pauson-Khand reaction to prepare the azabicyclo[3.3.1]nonane core, and (2) the Pt-catalyzed hydrosilation of enone C.