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Synfacts 2007(11): 1120-1120  
DOI: 10.1055/s-2007-991200
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Spongidepsin

Contributor(s): Philip Kocienski, Thomas Snaddon
G. Zhu, E.-i. Negishi*
Purdue University, West Lafayette, USA
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

In this synthesis of (-)-spongi­depsin the scope of the zirconium-catalyzed asymmetric carboalumination of alkenes (ZACA) reaction has been extended to include internally hydroxyl-substituted 1-alkenes (E.-i. Negishi and co-workers Proc. Nat. Acad. Sci. U.S.A. 2004, 101, 5782).