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Eur J Pediatr Surg 1994; 4: 19-21
DOI: 10.1055/s-2008-1066147
Original article

© Georg Thieme Verlag KG Stuttgart · New York

A Comparison of the Brain Weights of Normal, Untreated Hydrocephalic and Treated Hydrocephalic Rat Pups

Carys M. Bannister1,2 , J. J. Cranley2 , Valerie  Hillier3 , R.  Morrisey2 , K.  Street2
  • 1Department of Neurosurgery, Booth Hall Children's Hospital, Manchester M9 2AA, University of Manchester, Ml3 9PL, England
  • 2Department of Optometry and Vision Sciences, University of Manchester Institute of Science and Technology, M60 1QD, University of Manchester, Ml3 9PL, England
  • 3Department of Statistical Computation, School of Medicine, University of Manchester, Ml3 9PL, England
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Publication History

Publication Date:
25 March 2008 (online)

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Abstract

The dry brain weights of normal, untreated and treated hydrocephalic pups of Texas, Lewis and Texas/Lewis cross rats aged from 2 to 60 days were compared using the technique of generalised linear modelling. It was found that with increasing age there is a steadily progressive increase in the weight of the brains of the normal animals. The brains of the untreated hydrocephalics showed a normal increase in weight up to about the 25th day but after that whilst the weight continued to increase, it was significantly less than normal. On the other hand the weight gain of the brains of the treated hydrocephalic pups resembled that of the normals and steadily increase in weight throughout the period of observation.

Key words

Dry brain weight - Rat pups aged 2-60 days - Normal, untreated and treated hydrocephalics - Texas, Lewis and Texas/Lewis crosses