Planta Med 2020; 86(11): 732-748
DOI: 10.1055/a-1162-9988
Biological and Pharmacological Activity
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Herbal Products in Postsurgical Wound Healing – Incision, Excision and Dead Space Wound Models

Anna Herman
1   Faculty of Health Sciences, Warsaw School of Engineering and Health, Warsaw, Poland
,
Andrzej P. Herman
2   Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna near Warsaw, Poland
› Author Affiliations
Further Information

Publication History

received 20 February 2020
revised 19 April 2020

accepted 20 April 2020

Publication Date:
18 May 2020 (online)

Abstract

The purpose of this review is to summarize current knowledge acquired on preclinical (incision, excision, and dead space wound models) and clinical studies regarding topically used herbal products with wound healing activity. The antimicrobial, anti-inflammatory, and antioxidant mechanisms of their action as well as the adverse effects of herbal therapy will be described. Numerous preclinical and few clinical trials have confirmed the activity of herbal products in the stimulation of wound healing. In contrast to synthetic drugs, for which chemical compositions, purity, efficacy, minimal active concentration, and toxicity are well specified, several herbal formulations require further investigations. Nevertheless, it cannot be precluded that herbal products may be considered as an important support during conventional wound healing therapy or even as synthetic medicament replacements.

 
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