Synthesis
DOI: 10.1055/a-1403-4312
special topic
Special Issue dedicated to Prof. Sarah Reisman, recipient of the 2019 Dr. Margaret Faul Women in Chemistry Award

Total Synthesis of Mycocyclosin and the Herqulines

,
Corinna S. Schindler
This work was supported by the Alfred P. Sloan Foundation, the David and Lucile Packard Foundation, and the Camille and Henry Dreyfus Foundation (fellowships to C.S.S.).


Abstract

Since the first reports of their isolation, mycocyclosin and the herquline family of natural products have attracted interest from the synthetic community for their uniquely strained macrocyclic architectures. This review describes the attempted and successful total syntheses of these natural products and provides a summary of the strategies developed in the years since their isolation.

1 Introduction

2 Biosynthesis

3 Early Studies

4 Total Synthesis of Mycocyclosin

5 Overview

6 Wood’s Total Syntheses of Herqulines B and C

7 Baran’s Total Syntheses of Herqulines B and C

8 Schindler’s Total Syntheses of Herqulines B and C

9 Conclusions



Publication History

Received: 27 January 2021

Accepted after revision: 02 March 2021

Publication Date:
02 March 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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