Synthesis 2021; 53(17): 3019-3028
DOI: 10.1055/a-1482-2567
special topic
Bond Activation – in Honor of Prof. Shinji Murai

Generation of Aryllithium Reagents from N-Arylpyrroles Using Lithium

Tomoya Ozaki
,
Atsushi Kaga
,
,
This work was supported by the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Number JP19H00895) as well as by JST Core Research for Evolutional Science and Technology (CREST Grant Number JPMJCR19R4). H.Y. also thanks The Asahi Glass Foundation for financial support.


Abstract

Treatment of 1-aryl-2,5-diphenylpyrroles with lithium powder in tetrahydrofuran at 0 °C results in the generation of the corresponding aryllithium reagents through reductive C–N bond cleavage.

Supporting Information



Publication History

Received: 10 March 2021

Accepted after revision: 14 April 2021

Accepted Manuscript online:
14 April 2021

Article published online:
19 May 2021

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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