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Synthesis 2022; 54(17): 3899-3905
DOI: 10.1055/a-1504-8924
DOI: 10.1055/a-1504-8924
special topic
Special Issue in memory of Prof. Ferenc Fülöp
Synthesis of Cyclic Phosphinates by Microwave-Assisted Ionic-Liquid-Promoted Alcoholysis
This project was supported by the National Research, Development and Innovation Office (K134318). This project was also financed by the National Research, Development and Innovation Fund of Hungary in the frame of the FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project, as well as by FIKP-BIO. N.Z.K. is grateful for the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00130/19/7).
Dedicated to Professor Ferenc Fülöp on the occasion of his 70th birthday
Abstract
A series of 1-alkoxy-3-methyl- and 3,4-dimethyl-3-phospholene 1-oxides, as well as 1-alkoxy-3-methylphospholane 1-oxides were prepared in good yields by the microwave (MW)-assisted [bmim][PF6]-catalyzed transesterification of the corresponding methyl or ethyl esters. The alcoholyses studied represent another case, where MW irradiation has had a crucial role on the course of the reaction. The method developed is an alternative possibility to other esterifications starting from the corresponding phosphinic chlorides and acids.
Key words
alcoholysis - transesterification - phospholene oxide - phospholane oxide - microwave - ionic liquidSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1504-8924. Included are 31P and 1H NMR spectra together with LC chromatograms for products 1c–g, 2b–e and 3b–e.
- Supporting Information
Publication History
Received: 15 April 2021
Accepted after revision: 10 May 2021
Accepted Manuscript online:
10 May 2021
Article published online:
09 June 2021
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