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Synthesis 2021; 53(18): 3404-3408
DOI: 10.1055/a-1527-4526
DOI: 10.1055/a-1527-4526
special topic
Bond Activation – in Honor of Prof. Shinji Murai
A New Protocol for Catalytic Reduction of Alkyl Chlorides Using an Iridium/Bis(benzimidazol-2′-yl)pyridine Catalyst and Triethylsilane
I.R. and T.F. thank the Japan Society for the Promotion of Science (JSPS) for a Grant-in-Aid for Scientific Research (B) (No. 19H02722).
Abstract
The reduction of alkyl chlorides using triethylsilane is investigated. Primary, secondary, tertiary, and benzylic C–Cl bonds are effectively converted into C–H bonds using an [IrCl(cod)]2/2,6-bis(benzimidazol-2′-yl)pyridine catalyst system. This catalyst system is quite simple since the tridentate N-ligand can be easily prepared in one step from commercially available reagents.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1527-4526.
- Supporting Information
Publication History
Received: 30 April 2021
Accepted after revision: 11 June 2021
Accepted Manuscript online:
11 June 2021
Article published online:
01 July 2021
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