Synthesis, Inhaltsverzeichnis Synthesis 2021; 53(22): 4272-4278DOI: 10.1055/a-1538-8429 special topic Special Issue dedicated to Prof. Sarah Reisman, recipient of the 2019 Dr. Margaret Faul Women in Chemistry Award A de novo Synthesis of Oxindoles from Cyclohexanone-Derived γ-Keto-Ester Acceptors Using a Desaturative Amination–Cyclization Approach Authors Institutsangaben Henry P. Caldora‡ a Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK Sebastian Govaerts‡ a Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK Shashikant U. Dighe a Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK Oliver J. Turner b Oncology R&D, Research & Early Development, AstraZeneca, Darwin building, 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK Daniele Leonori ∗ a Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK Artikel empfehlen Abstract Artikel einzeln kaufen(opens in new window) Alle Artikel dieser Rubrik(opens in new window) Dedicated to Prof Sarah Reisman in recognition on her award of the inaugural Margaret Faul Women in Chemistry Award. Abstract Here we report a desaturative approach for oxindole synthesis. This method uses simple ethyl 2-(2-oxocyclohexyl)acetates and primary amine building blocks as coupling partners. A dual photoredox–cobalt manifold is used to generate a secondary aniline that, upon heating, cyclizes with the pendent ester functionality. 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