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Synthesis 2022; 54(21): 4711-4720
DOI: 10.1055/a-1633-8792
special topic
Asymmetric C–H Functionalization

Direct Copper-Catalyzed C-3 Arylation of Diphenylphosphine Oxide Indoles

Xiao-Ling Huang
a   State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
,
Chong Li
a   State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
,
Juan Wang
a   State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
,
Shang-Dong Yang  ∗
a   State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
b   State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Lanzhou 730000, P. R. of China
› Author AffiliationsWe are grateful to the National Natural Science Foundation of China (NSFC, No. 21532001), the International Joint Research Center for Green Catalysis and Synthesis (No. 2016B01017), and Lanzhou University for their financial support.
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Abstract

We have developed a simple and effective method for the C-3 arylation of phosphorus-containing indole compounds in the presence of CuI under mild conditions. This reaction provides a reliable method for the modification of ligands.

Key words

transition-metal catalysis - organophosphorus compounds - arylation - indoles

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-1633-8792.
  • Supporting Information


Publication History

Received: 09 August 2021

Accepted after revision: 03 September 2021

Accepted Manuscript online:
03 September 2021

Article published online:
14 October 2021

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