Synthesis
DOI: 10.1055/a-1683-9455
special topic
Asymmetric C–H Functionalization

Cationic Iridium/Chiral Bidentate Phosphoramidite Catalyzed Asymmetric Hydroarylation

a  Department of Materials Science and Engineering, National Institute of Technology, Kochi College Otsu, Monobe, Nangoku, Kochi 783-8508, Japan
,
b  Division of Chemical Process Engineering and Frontier Chemistry Center (FCC), Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-8628, Japan
› Author Affiliations


Abstract

In this personal account, we summarize our investigations on the asymmetric direct addition of C(sp2)–H bonds to unsaturated bonds, such as C=O and C=C, using cationic iridium/chiral O-linked bidentate phosphoramidite (Me-BIPAM) and S-linked bidentate phosphoramidite (S-Me-BIPAM) catalyst systems.

1 Introduction

2 Highly Enantioselective Intramolecular Hydroarylation of α-Keto Amides

3 Highly Enantioselective Intermolecular Hydroarylation of Bicyclo­alkenes

4 Conclusion



Publication History

Received: 05 October 2021

Accepted after revision: 01 November 2021

Publication Date:
01 November 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
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