Synthesis
DOI: 10.1055/a-1702-5062
short review

Recognition of Symmetry as a Powerful Tool in Natural Product Synthesis

Corinna S Schindler
1  Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States (Ringgold ID: RIN114460)
,
Lara Cala
2  Chemistry, University of Michigan, Ann Arbor, United States (Ringgold ID: RIN1259)
,
Mario A Gaviria
3  Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States (Ringgold ID: RIN114460)
,
Scott L Kim
4  Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States (Ringgold ID: RIN114460)
,
Trenton R Vogel
5  Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States (Ringgold ID: RIN114460)
› Author Affiliations
Supported by: Alfred P. Sloan Foundation
Supported by: Camille and Henry Dreyfus Foundation
Supported by: National Science Foundation CHE-1654223
Supported by: David and Lucile Packard Foundation

The design of concise and efficient synthetic strategies to access naturally occurring, pharmaceutically active complex molecules is of utmost importance in current chemistry. It not only enables rapid access to these molecules and their analogues but also provides sufficient quantities for their biological evaluation. Identification of any symmetric or pseudosymmetric synthetic intermediates upon retrosynthetic bond disconnection of the target molecule holds the promise to significantly streamline the route towards the compound of interest. This review will highlight recent examples of successful natural product syntheses reported within the past five years that benefited from the recognition of symmetry elements during the retrosynthetic design.



Publication History

Received: 11 August 2021

Accepted after revision: 22 November 2021

Publication Date:
22 November 2021 (online)

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