Synthesis
DOI: 10.1055/a-1702-5062
short review

Recognition of Symmetry as a Powerful Tool in Natural Product Synthesis

Corinna S Schindler
1   Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States (Ringgold ID: RIN114460)
,
Lara Cala
2   Chemistry, University of Michigan, Ann Arbor, United States (Ringgold ID: RIN1259)
,
Mario A Gaviria
3   Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States (Ringgold ID: RIN114460)
,
Scott L Kim
4   Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States (Ringgold ID: RIN114460)
,
Trenton R Vogel
5   Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States (Ringgold ID: RIN114460)
› Institutsangaben
Gefördert durch: Alfred P. Sloan Foundation
Gefördert durch: Camille and Henry Dreyfus Foundation
Gefördert durch: National Science Foundation CHE-1654223
Gefördert durch: David and Lucile Packard Foundation

The design of concise and efficient synthetic strategies to access naturally occurring, pharmaceutically active complex molecules is of utmost importance in current chemistry. It not only enables rapid access to these molecules and their analogues but also provides sufficient quantities for their biological evaluation. Identification of any symmetric or pseudosymmetric synthetic intermediates upon retrosynthetic bond disconnection of the target molecule holds the promise to significantly streamline the route towards the compound of interest. This review will highlight recent examples of successful natural product syntheses reported within the past five years that benefited from the recognition of symmetry elements during the retrosynthetic design.



Publikationsverlauf

Eingereicht: 11. August 2021

Angenommen nach Revision: 22. November 2021

Publikationsdatum:
22. November 2021 (online)

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany