Synthesis
DOI: 10.1055/a-1712-0912
short review

Recent Advances in Catalytic Nonenzymatic Kinetic Resolution of Tertiary Alcohols

Bo Ding
1  College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China (Ringgold ID: RIN12390)
,
Qilin Xue
1  College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China (Ringgold ID: RIN12390)
,
Shihu Jia
1  College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China (Ringgold ID: RIN12390)
,
Hong-Gang Cheng
2  College of Chemistry and Molecular Sciences, Wuhan University, Wuhan University, Wuhan, China
,
Qianghui Zhou
3  College of Chemistry and Molecular Sciences, Wuhan University, Wuhan University, Wuhan, China
› Author Affiliations
Supported by: National Natural Science Foundation of China 21801193, 21871213, 22071189

The kinetic resolution (KR) of racemates is one of the most widely used approaches to access enantiomerically pure compounds. Over the past two decades, catalytic nonenzymatic KR has gained popularity in the field of asymmetric synthesis due to the rapid development of chiral catalysts and ligands in asymmetric catalysis. Chiral tertiary alcohols are prevalent in a variety of natural products, pharmaceuticals, and biologically active chiral compounds. The catalytic nonenzymatic KR of racemic tertiary alcohols is a straightforward strategy to access enantioenriched tertiary alcohols. This short review describes recent advances in catalytic nonenzymatic KR of tertiary alcohols, including organocatalysis and metal catalysis.



Publication History

Received: 04 November 2021

Accepted after revision: 02 December 2021

Publication Date:
02 December 2021 (online)

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