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Recent Advances in Catalytic Nonenzymatic Kinetic Resolution of Tertiary AlcoholsSupported by: National Natural Science Foundation of China 21801193, 21871213, 22071189
The kinetic resolution (KR) of racemates is one of the most widely used approaches to access enantiomerically pure compounds. Over the past two decades, catalytic nonenzymatic KR has gained popularity in the field of asymmetric synthesis due to the rapid development of chiral catalysts and ligands in asymmetric catalysis. Chiral tertiary alcohols are prevalent in a variety of natural products, pharmaceuticals, and biologically active chiral compounds. The catalytic nonenzymatic KR of racemic tertiary alcohols is a straightforward strategy to access enantioenriched tertiary alcohols. This short review describes recent advances in catalytic nonenzymatic KR of tertiary alcohols, including organocatalysis and metal catalysis.
Received: 04 November 2021
Accepted after revision: 02 December 2021
02 December 2021 (online)
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