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Synthesis 2022; 54(11): 2585-2594
DOI: 10.1055/a-1748-6564
DOI: 10.1055/a-1748-6564
feature
Addition/Substitution Approach of TsNHCH2SiMe2CH2Cl with Isocyanates or Isothiocyanates To Construct 1,3,5-Diazasilinan-2-ones or 1,3,5-Thiazasilinan-2-imines
We are grateful for the financial support from the National Natural Science Foundation of China (21921002, 22171191), the Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China (2020LF2003), and the Science and Technology Department of Sichuan Province (2020YFS0186).
Abstract
TsNHCH2SiMe2CH2Cl has been exploited as a 1,4-dipole synthon for the synthesis of 1,3,5-diazasilinan-2-ones by a sequential N-addition/N-substitution process with isocyanates, or for the synthesis of 1,3,5-thiazasilinan-2-imines with isothiocyanates by a sequential N-addition/S-substitution process.
Key words
silaazacycles - ‘carbon-silicon’ switching - 1,3,5-diazasilinan-2-one - 1,3,5-thiazasilinan-2-imine - cyclizationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1748-6564.
- Supporting Information
Publication History
Received: 31 December 2021
Accepted after revision: 24 January 2022
Accepted Manuscript online:
24 January 2022
Article published online:
03 March 2022
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