Synthesis, Table of Contents Synthesis 2023; 55(16): 2586-2594DOI: 10.1055/a-2067-4165 paper Special Issue Honoring Prof. Guoqiang Lin’s Contributions to Organic Chemistry Synthesis of Triarylphosphines via Cu-Catalyzed Coupling of Aryl Halides and Acylphosphines Authors Minghui Xu Zhengping Zhu Haojie Yi Hong Zhu∗ Zhiqian Wang ∗ Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Dedicated to Professor Guo-Qiang Lin on the occasion of his 80th birthday Abstract A Cu-catalyzed C(sp2)–P bond forming reaction using an acylphosphine as the phosphorus source is reported; with CuCl2 as the catalyst, 34 examples of aryl iodides and bromides were converted into triarylphosphines in good to excellent yield. A preliminary study of the mechanism was carried out and found that a radical intermediate is not involved. This reaction is an extension of the application of acylphosphines in Cu-catalyzed reactions and shows their potential as a phosphination reagent in the synthesis of tertiary phosphines. Key words Key wordsCu catalysis - acylphosphines - C(sp2)–P bond formation - triarylphosphine - phosphination reagent Full Text References References 1a Jiang T, Zhang H, Ding Y, Zou S, Chang R, Huang H. Chem. Soc. Rev. 2020; 49: 1487 1b Surry DS, Buchwald SL. Angew. Chem. Int. Ed. 2008; 47: 6338 1c Xie J.-H, Zhou Q.-L. Acc. Chem. Res. 2008; 41: 581 1d Yang J, Chen X, Wang Z. Tetrahedron Lett. 2015; 56: 5673 2a Fernández-Pérez H, Etayo P, Panossian A, Vidal-Ferran A. Chem. Rev. 2011; 111: 2119 2b Genet J.-P, Ayad T, Ratovelomanana-Vidal V. Chem. Rev. 2014; 114: 2824 2c Xie C, Smaligo AJ, Song X.-R, Kwon O. ACS Cent. Sci. 2021; 7: 536 2d Zhang W, Chi Y, Zhang X. Acc. Chem. Res. 2007; 40: 1278 2e Zheng S, Lu X. Org. Lett. 2009; 11: 3978 3a Balueva AS, Musina EI, Karasik AA. 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