Synthesis 2024; 56(04): 693-699
DOI: 10.1055/a-2102-1192
special topic
Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

One-Pot Telescopic Approach to Synthesize Disubstituted Benz­imidazoles in Deep Eutectic Solvent

Soumyadip Das
,

K.C. would like to thank the administration of the Vellore Institute of Technology for offering seed money as a research grant.


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Abstract

An ongoing challenge in the pharmaceutical sector is the need to find and implement novel synthetic approaches because traditional methods sometimes violate the principles of green chemistry. While benzimidazoles are of great importance as building blocks for the creation of molecules having pharmacological activity, the development of methods for their sustainable synthesis has been a challenge for organic synthesis. Herein, we have carried out a one-pot telescopic approach to the synthesis of disubstituted benzimidazole derivatives in a deep eutectic solvent (DES) medium to investigate an alternate synthetic technique. Starting with methyl 4-fluoro-3-nitrobenzoate, SNAr reaction, reduction, and cyclization were performed with choline chloride/glycerol/H2O as DES medium, which gave the best performance out of the five DESs examined. We report the synthesis of disubstituted benzimidazoles via one-pot telescopic approach.

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Publikationsverlauf

Eingereicht: 04. März 2023

Angenommen nach Revision: 26. Mai 2023

Accepted Manuscript online:
26. Mai 2023

Artikel online veröffentlicht:
03. Juli 2023

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