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Synthesis 2024; 56(04): 573-576
DOI: 10.1055/a-2169-6200
DOI: 10.1055/a-2169-6200
special topic
Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)
Bis(pinacoloto)diboron/4-Phenylpyridine System for One-Pot Photocatalyzed Borylation and Reduction of Aldehyde: Synthesis of Tavaborole in a Flow Reactor
The authors acknowledge financial support from National Institute of Pharmaceutical Education and Research Kolkata, and Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India.
Abstract
A photocatalyzed one-pot borylation of haloarene and reduction of aldehyde by cocatalysis of bis(pinacoloto)diboron/4-phenylpyridine is reported. The reaction was carried out in a flow reactor by irradiating the reaction at 410 nm, with residence time of 10 minutes. The method was successfully applied for the synthesis of tavaborole in a single step with 81% yield.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2169-6200.
- Supporting Information
Publication History
Received: 24 July 2023
Accepted after revision: 06 September 2023
Accepted Manuscript online:
06 September 2023
Article published online:
02 November 2023
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