Synergistic Pd/Cu-Catalyzed Asymmetric Csp³–Csp³ Coupling of 1,3-Dienes with 2-Acylimidazoles

Abstract

The catalytic asymmetric coupling of 1,3-dienes with carbon nucleophiles is an important process for forming Csp³–Csp³ bonds. Here, we describe a synergistic Pd/Cu-catalyzed coupling of 1,3-dienes with 2-acylimidazoles. This reaction produces 2-acylimidazole derivatives that have α,β-adjacent stereocenters in moderate yields with good to excellent stereoselectivity.

Key words

synergistic catalysis - palladium - copper - Csp³–Csp³ coupling - 2-acylimidazoles - 1,3-dienes

Publikationsverlauf

Eingereicht: 20. September 2024

Angenommen nach Revision: 29. Oktober 2024

Accepted Manuscript online:
29. Oktober 2024

Artikel online veröffentlicht:
03. Dezember 2024

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