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Synthesis
DOI: 10.1055/a-2617-6013
DOI: 10.1055/a-2617-6013
Paper
Published as part of the Special Topic Dedicated to Prof. Paul Knochel
Nickel-Catalyzed Alkylcarbonylation of α-Trifluoromethyl-Substituted Styrenes via Selective Monodefluorinative Strategy
Gefördert durch: Jiangsu Specially Appointed Professors Plan SR10900122
Gefördert durch: Natural Science Foundation of Jiangsu Province BK20221355,BK20231521
Gefördert durch: National Natural Science Foundation of China 22322108
Dedication
Dedicated to Professor Paul Knochel on the occasion of his 70th birthday.
Abstract
A highly selective nickel-catalyzed monodefluorinative alkylcarbonylation between α-trifluoromethyl-substituted styrenes and alkylzinc pivalates under 1 atm of CO gas is disclosed, thus providing an expedient approach to the synthesis of polyfunctionalized gem-difluoroalkenes under mild reaction conditions. Control experiments highlight the superior reactivity of alkylzinc pivalates compared to convensional alkylzinc halides. Moreover, this method is distinguished by its ample scope and facile derivatization of the resulting products for increasing functional molecular complexity via a sequential defluorinative strategy.
Publikationsverlauf
Eingereicht: 26. April 2025
Angenommen nach Revision: 20. Mai 2025
Accepted Manuscript online:
20. Mai 2025
Artikel online veröffentlicht:
11. August 2025
© 2025. Thieme. All rights reserved.
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