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Synthesis
DOI: 10.1055/a-2705-6689
Paper

Efficient oxidation of internal alkynes to 1,2-diketone compounds catalyzed by a binuclear ruthenium complex

Fei Xie
1   State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, School of Chemical Engineering, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399)
,
Sheng Zhang 
1   State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, School of Chemical Engineering, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399)
,
Xiujuan Feng
2   State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China
,
Xiao-Qiang Yu
2   State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China
,
Xuan Zhang
1   State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, School of Chemical Engineering, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399)
,
Ming Bao
1   State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, School of Chemical Engineering, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399)
› Author Affiliations
Supported by: Fundamental Research Funds for the Central Universities DUT22LAB612,DUT24ZD132
Supported by: National Natural Science Foundation of China 22172014,22372024
Supported by: Foundation of Guizhou Educational Committee qianjiaoji [2023] 088
Supported by: “Excellence Co-Innovation Program” International Exchange Fund Project DUTIO-ZG-202505
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Structurally methane monooxygenase (MMO) active site-like new binuclear ruthenium complex-catalyzed oxidation of internal alkynes is described. The direct catalytic oxidation of internal alkynes proceeded smoothly and completed within 15 minutes in the presence of NaIO4 as the oxidant to produce 1,2-diketone products in high to excellent yields. The binuclear ruthenium complex can be easily prepared and handled, and which has high catalytic activity (TOFmax = 5778 h-1) and a long lifetime (TONmax = 52000). Various synthetically useful functional groups, such as halogen atoms, acetyl, and TMS, remain intact during the oxidation of internal alkynes.



Publication History

Received: 13 July 2025

Accepted after revision: 02 September 2025

Accepted Manuscript online:
19 September 2025

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