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Synthesis
DOI: 10.1055/a-2744-6756
DOI: 10.1055/a-2744-6756
Paper
Published as part of the Special Issue in Honor of Dr. Dani Schultz, the 2025 Women
in Chemistry Award Winner
Synthesis of Modified Fusicoccane Diterpenoids via Diverging MHAT Reactivity
Autoren
Support was provided by the NSF (CHE 2155228 and GRF to D.W.S.), the Skaggs Graduate School (S.A.F.), and the NIH (GM122606).
Gefördert durch: NSF CHE 2155228
Gefördert durch: NIH GM122606
Gefördert durch: National Science Foundation Graduate Research Fellowship Program 2235200
Dedication
Dedicated to Dr. Dani Schultz for her outstanding leadership, scholarship, and science communication.
Abstract
Cotylenin and fusicoccin diterpene glycosides modulate the stability of 14-3-3 protein–client interactions. Here, we report the divergent syntheses of representative aglycons, brassicicene (BR-I), and talarmalnoid B (Tal-B) by modification of Studer’s Mukaiyama hydration variant.
Publikationsverlauf
Eingereicht: 27. September 2025
Angenommen nach Revision: 11. November 2025
Artikel online veröffentlicht:
27. November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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