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DOI: 10.1055/a-2746-2379
Concise Synthesis of the Hexasaccharide Repeating Unit of the Cell Wall O-Antigen of Enterotoxigenic Escherichia coli O140 Strain
Autoren
Abstract
A straightforward synthetic strategy has been developed for the synthesis of the hexasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O140 strain in good yield. Several stereoselective 1,2-cis and 1,2-trans glycosylations have been carried out exploiting the presence of the functional group in the glycosyl donor and selection of reaction solvents. A late-stage oxidation of the primary hydroxyl group to the carboxylic functionality has been carried out by the TEMPO-mediated oxidation in a phase transfer condition. The synthesis of the hexasaccharide was carried out by [2+2+1+1] glycosylations.
Primary Data
For this article, data are available online at http://www.thieme-connect.com/ejournals/toc/ synthesis and can be cited using the following DOI: 10.1055/a-2746-2379
Publikationsverlauf
Eingereicht: 02. September 2025
Angenommen nach Revision: 11. November 2025
Artikel online veröffentlicht:
27. November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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