Synthesis 2009(1): 160-164  
DOI: 10.1055/s-0028-1083277
© Georg Thieme Verlag Stuttgart ˙ New York

The Thermal Amidation of Carboxylic Acids Revisited

Lukas J. Gooßen*, Dominik M. Ohlmann, Paul P. Lange
Fachbereich Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Straße 54, 67663 Kaiserslautern, Germany
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Publication History

Received 12 November 2008
Publication Date:
12 December 2008 (online)


Factors affecting the thermal condensation of carboxylic acids with amines have been investigated, and an effective protocol for this waste-minimized, environmentally benign transformation has been identified. Fourteen examples demonstrate the applicability of this procedure to aliphatic, aromatic and heteroaromatic carboxylic acids and primary and secondary aliphatic as well as aromatic amines. The approach leads to the corresponding amides in good yields.