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Synthesis 2011(16): 2590-2594  
DOI: 10.1055/s-0030-1260075
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© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Mediated Olefination of 2-(tert-Butyldimethylsilyl)pyridine by sp³ C-H Activation

Cong Wang, Haibo Ge*
Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202-3274, USA
Fax: +1(317)2744701; e-Mail: geh@iupui.edu;
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Publication History

Received 9 April 2011
Publication Date:
17 June 2011 (online)

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Abstract

An unprecedented direct alkenylation of 2-(tert-butyl­dimethylsilyl)pyridine with acrylates through palladium-mediated C-H activation on a nonacidic sp³ carbon is reported. This method provides an efficient approach to allylsilanes.

Key words

palladium - olefination - pyridine

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