Aziridine-2-carboxaldehyde Dimers Undergo Homo-Ugi 4-Component-5-center Reactions

Abstract

Dimeric α-aziridine aldehydes have been used as the aldehyde component in Ugi and Passerini reactions. The highly reactive mixed anhydride intermediate is subject to nucleophilic attack by the aziridine, leading to ‘homo-Ugi’ β-acylaziridinyl-α-aminoamides. The products can be readily transformed into substituted lactones.

Key words

aziridines - aldehydes - multicomponent reactions - heterocycles - amphoteric molecules

• References

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