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Synlett 2013; 24(3): 298-300
DOI: 10.1055/s-0032-1318215
cluster
© Georg Thieme Verlag Stuttgart · New York

Cluster Preface: Process Chemistry

Nobuyoshi Yasuda*
Process Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA   eMail: nobuyoshi_yasuda@merck.com
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Publikationsverlauf

Received: 24. Januar 2013

Accepted: 24. Januar 2013

Publikationsdatum:
05. Februar 2013 (online)

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Abstract

The goal of process chemistry is to identify cost-effective, robust and environmentally friendly manufacturing routes for drug candidates. This article outlines the importance of scientific ­innovation to overcome the many challenges along the journey ­towards a drug filing. ��

Key words

manufacturing processes - cost efficiency - reproducibility - ease of operation - safety - green chemistry - reaction ­mechanisms
 

  • References

  • 1 Yasuda N, Tan L. Efavirenz a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), and a Previous Structurally Related Development Candidate. In The Art of Process Chemistry. Yasuda N. Wiley-VCH; Weinheim: 2011. Chap. 10, 1–43
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